Recombinant Human IL6RA/CD126 protein (His tag)

SKU: PDMH100399

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:IL6RA;CD126

Target Synonym:Membrane glycoprotein;CD126;gp80;IL6Q;IL-6R;IL-6R 1;IL-6R subunit alpha;IL-6R-1;IL6RA;IL-6RA;IL-6R-Alpha;IL6RQ;Interleukin-6 receptor subunit alpha;Membrane glycoprotein 80;IL6R;IL-6Rαalpha;CD 126;CD126 antigen;IL 6R;IL 6R 1;IL 6R alpha;IL-6 receptor alpha chain;IL-6 receptor subunit alpha;IL-6R 1 Membrane glycoprotein 80 (gp80);Interleukin 6 receptor;MGC30256

Research Areas:immunology;Stem cells

Conjugation:

Target Species:Human

Expression Host:HEK293 Cells

Application:

Fusion tag:C-His

UNIProt ID:P08887

Accession:P08887

Background:Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

Concentration:

Activity:Not validated for activity

Sequence:Met1-Pro365

Purity: > 95% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:40.0 kDa

ObservedMW:70 kDa