Recombinant Human IL-17B protein

SKU: CD01553

Size:5 ug

Background:The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Research_area:Immunology

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Interleukin-17B

Biological activity:Fully biologically active when compared to standard. The ED5 as determined by inducing IL-8 secretion of human HepG2 cells is less than 1. μg/ml, corresponding to a specific activity of > 1 IU/mg.

Synonyms:IL-17B, IL17B, IL-2, NIRF, ZCYTO7,Human

Endotoxin:Less than 0.1 EU/μg of rHuIL-17B as determined by LAL method.

Storage:-20ºC

Sequence:MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F

uniprot accession:Q9UHF5

Molecular weight:Approximately 36.5 kDa, a non-disulfide-linked homodimer of two 161 amino acid polypeptide chains.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4, with .1 % Tween-2 and 3 % Trehalose.