Recombinant Human IGFBP1 Protein(Trx Tag)

SKU: PDEH100473

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:IGFBP1

Target Synonym:IGF-binding protein;Insulin-like growth factor-binding protein;IGF-BP;hIGFBP;IBP;IGFBP1;AFBP;IBP1;IGF-BP25;PP12;hIGFBP-1;IBP-1;IGF-binding protein 1;IGFBP-1;Insulin-like growth factor-binding protein 1;placental protein 12;Alpha pregnancy associated endometrial globulin;Amniotic fluid binding protein;Binding protein 25;Binding protein 26;Binding protein 28;Growth hormone independent binding protein;hIGFBP 1;hIGFBP1;IBP 1;IGF binding protein 1;IGF BP25;IGFBP 1;Insulin like growth factor binding protein 1;PP 12

Research Areas:Metabolism;Developmental Biology;Signal Transduction

Conjugation:

Target Species:Human

Expression Host:E.coli

Application:

Fusion tag:N-Trx

UNIProt ID:P08833

Accession:P08833

Background:IGFBP1, also known as IGFBP-1 and insulin-like growth factor-binding protein 1, is a member of the insulin-like growth factor-binding protein family. IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth-promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGFBP1 has an IGFBP domain and a thyroglobulin type-I domain. It binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. The binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

Concentration:

Activity:Not validated for activity

Sequence:Ala26-Asn259

Purity:> 95% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Endotoxin:< 10 EU/mg of the protein as determined by the LAL method

Calculated MW:44 kDa

ObservedMW:48 kDa