Recombinant Human IFN- Alpha 1a protein

SKU: CD01614

Size:20 ug

Background:IFN-αs are proteins secreted by leukocyte. They are mainly involved in innate immune response against viral infection. The IFN-α family has 13 subtypes and 23 different variants. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-α subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxy-terminal end.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Interferon-alpha1a

Biological activity:Fully biologically active when compared to standard. The specific activity determined by an anti-viral assay is no less than 1. × 18 IU/mg.

Synonyms:IFN-α1a,IFN-alpha-2, IFN-alphaA, IFNAB, leIF A, IFNA2,IFNA1, Human

Endotoxin:Less than 0.1 EU/μg of rHuIFN-α1a as determined by LAL method.

Storage:-20ºC

Sequence:MCDLPETHSL DNRRTLMLLA QMSRISPSSC LMDRHDFGFP QEEFDGNQFQ KAPAISVLHE LIQQIFNLFT TKDSSAAWDE DLLDKFCTEL YQQLNDLEAC VMQEERVGET PLMNADSILA VKKYFRRITL YLTEKKYSPC AWEVVRAEIM RSLSLSTNLQ ERLRRKE

uniprot accession:P1562;LN195

Molecular weight:Approximately 19.5 kDa, a single non-glycosylated polypeptide chain containing 167 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered solution in PBS, pH 7.4, containing 3 % Mannitol, 5 % Trehalose, .5 % Tween-8.