Recombinant Human CD155/PVR/NECL5 Protein (His Tag)

SKU: PKSH033563

Size: 50μg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Immune Checkpoint Proteins

Abbreviation: CD155;PVR;NECL5

Target Synonym: CD155;NECL-5;Nectin-Like Protein 5;PVR;PVS;Poliovirus Receptor

Research Areas: Microbiology

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application: BLI

Fusion tag: C-His

UNIProt ID: A0A0C4DG49

Accession: NP_006496

Background: Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV); an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains; a transmembrane segment; and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (α; β; γ; and δ) with identical extracellular domains.

Concentration:

Activity: Loaded Human TIGIT-Fc on Protein A Biosensor, can bind Human PVR-His with an affinity constant of 4.22 nM as determined in BLI assay.

Sequence: Trp21-Asn343

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 36.1 kDa

ObservedMW: 58 kDa