Recombinant Human BAFF Receptor protein

SKU: CD02285

Size:10 ug

Background:B Cell Activating Factor Receptor (BAFF-R), also named tumor necrosis factor receptor superfamily member 13C, is a member of the TNFR superfamily. It is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFF receptor is a type III transmembrane protein containing a single extracellular phenylalanine-rich domain and binds with high specificity to BAFF (TNFSF13B). It enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. BAFF receptor/BAFF signaling plays a critical role in B cell survival and maturation.

Research_area:Immunology

Purity:> 95 % by reduced SDS-PAGE analyses.

Source:Escherichia coli.

Full product name:Recombinant Human B Cell Activating Factor Receptor

Biological activity:Fully biologically active when compared to standard. The ED5 as determined by its ability to block BAFF induced mouse splenocyte survival is 1.-5. μg/ml in the presence of 1. μg/ml of rHuBAFF.

Synonyms:TNFRSF13C,BAFF Receptor, BAFF-R, BAFFR, BROMIX, CD268, CVID4, prolixin,Human

Endotoxin:Less than 1 EU/μg of rHuBAFF-R as determined by LAL method.

Storage:-20ºC

Sequence:MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG

uniprot accession:Q96RJ3;Q5H8V1; C8ZLJ6

Molecular weight:Approximately 7.8 kDa, a single non-glycosylated polypeptide chain containing 76 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM PB, pH 8., 5 mM NaCl.