Recombinant Human AITR Ligand/TNFSF18 protein

SKU: CD02368

Size:5 ug

Background:AITR Ligand (activation-inducible TNF receptor superfamily member ligand) is also named GITR Ligand (glucocorticoid-induced tumor necrosis factor receptor ligand) and TNFRSF18, regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. The AITRL gene codes for a type II transmembrane protein comprised of 177 amino acids, including a 28 amino acid cytoplasmic region, a 21 amino acid transmembrane domain and a 128 amino acid extracellular domain. Recombinant human AITRL is a 14.3 kDa protein, containing 126 amino acid residues corresponding to the extracellular domain of AITR Ligand.

Research_area:Others

Purity:> 98 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Activation-induced TNFR member Ligand/TNFSF18

Biological activity:Fully biologically active when compared to standard. The biological activity as determined by stimulation of IL-8 production using human PBMC is in a concentration range of .1-1 ng/ml.

Synonyms:AITR Ligand/TNFSF18, AITR, CD357, ENERGEN, GITR, GITR-D,Human

Endotoxin:Less than 0.1 EU/μg of rHuAITR Ligand/TNFSF18 as determined by LAL method.

Storage:-20ºC

Sequence:ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLIYGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE LHVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFIS

uniprot accession:Q9UNG2

Molecular weight:Approximately 14.3 kDa, a single non-glycosylated polypeptide chain containing 126 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH7.4.