Recombinant HSD17B1 Monoclonal Antibody

SKU: AN301846L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:HSD17B1

Target Synonym:HSD;EDHB;HSD17B;SDR28C;HSD17B1;17-beta-HSD;20-alpha-HSD;E2DH;EDH17B2;EDHB17;HSD17;SDR28C1;E17KSR;EDH17B1;17 beta HSD 1;17 beta hydroxysteroid dehydrogenase type 1;17-beta-HSD 1;17-beta-hydroxysteroid dehydrogenase type 1;20 alpha-hydroxysteroid dehydrogenase;DHB1;Estradiol 17 beta dehydrogenase 1;Estradiol 17-beta-dehydrogenase 1;Hydroxysteroid (17 beta) dehydrogenase 1;member 1;MGC13814;Placental 17 beta hydroxysteroid dehydrogenase;Placental 17-beta-hydroxysteroid dehydrogenase;Short chain dehydrogenase/reductase family 28CE

Research Areas:Signal Transduction;Neuroscience;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A558

UNIProt ID:P14061

Accession:

Background:HSD17B1 is a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. HSD17B1 catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. HSD17B1 is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate.

Concentration:1 mg/mL

Immunogen:Recombinant human HSD17B1 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:5000-1:20000;IHC 1:1000-1:5000

Calculated MW:35 kDa

ObservedMW:35 kDa