Recombinant EphA2 Monoclonal Antibody

SKU: AN301514L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:EphA2

Target Synonym:ARCC;CTPP;EPHA;Ephrin type-A receptor;CTRCT;ARCC2;CTPA;CTPP1;CTRCT6;ECK;EPHA2;Ephrin type-A receptor 2;Epithelial cell kinase;Tyrosine-protein kinase receptor ECK;AW545284;EPH receptor A2;Myk2;Sek2;Sek-2

Research Areas:Cardiovascular;Neuroscience;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A213

UNIProt ID:P29317

Accession:

Background:Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway.

Concentration:1 mg/mL

Immunogen:Recombinant human EphA2 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IHC 1:200-1:1000

Calculated MW:109 kDa

ObservedMW:130 kDa