Recombinant E2F-1 Monoclonal Antibody

SKU: AN301368L

Size::

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:E2F-1

Target Synonym:RBP;RBAP;RBBP;E2F;E2F-1;RBAP1;RBBP3;RBP3;E2F1

Research Areas:Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:5F4

UNIProt ID:Q01094

Accession:

Background:The protein encoded by this gene is a member ofThe E2F family of transcription factors.The E2F family plays a crucial role inThe control of cell cycle and action of tumor suppressor proteins and is also a target ofThe transforming proteins of small DNA tumor viruses.The E2F proteins contain several evolutionally conserved domains found in most members ofThe family. These domains include a DNA binding domain, a dimerization domain which determines interaction withThe differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded withinThe transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human E2F-1 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000

Calculated MW:47 kDa

ObservedMW:60 kDa