Recombinant DYNLL1 Monoclonal Antibody

SKU: AN301509L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:DYNLL1

Target Synonym:DNCL;hdlc;Dynein Light Chain LC8-Type;DYNLL;DNCLC;DLC;DYNLL1;DLC1;DLC8;DNCL1;DNCLC1;LC8;LC8a;PIN;hdlc1;8 kDa Dynein Light Chain;Dynein Light Chain 1 Cytoplasmic;Dynein Light Chain LC8-Type 1;Protein Inhibitor of Neuronal Nitric Oxide Synthase;8kDLC;cytoplasmic;Cytoplasmic dynein light polypeptide;DYL1;Dynein;Dynein light chain 1;Dynein light chain LC8 type 1;HDLC1;LC8-type 1;light chain;light chain 1;light polypeptide 1;MGC126137;MGC126138;MGC72986;Protein inhibitor of neuronal NOS

Research Areas:Cell Biology;Neuroscience;Signal Transduction;Epigenetics and Nuclear Signaling;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A208

UNIProt ID:P63167

Accession:

Background:Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

Concentration:1 mg/mL

Immunogen:Recombinant human DYNLL1 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:5000;IHC 1:100

Calculated MW:10 kDa

ObservedMW:10 kDa