Recombinant CD70 Monoclonal Antibody

SKU: AN301838L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:CD70

Target Synonym:Tumor necrosis factor ligand superfamily member;TNFSF;CD70;CD27-L;CD27L;CD27LG;TNFSF7;TNLG8A;CD27 ligand;CD70 antigen;Tumor necrosis factor ligand superfamily member 7;Ki-24;CD27L;TNFSF7;CD 27L;CD 70;CD27 L;CD27 LG;CD70 molecule;Ki 24 antigen;Ki24 antigen;member 7;sCD27 Ligand;soluble CD27 Ligand;Surface antigen CD70;TNFSF 7;Tumor necrosis factor (ligand) superfamily

Research Areas:Immunology;Cancer;Stem Cells

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A550

UNIProt ID:P32970

Accession:

Background:CD70 is a type II transmembrane glycoprotein and a member of the tumor necrosis factor ligand superfamily (TNFSF), also known as CD27L and TNFSF7. It is normally expressed on medullary thymic epithelial cells. Its expression is induced on activated lymphoid cells (B cells, T cells, and NK cells) and dendritic cells. CD70 is a ligand for CD27, a co-stimulatory receptor that plays an important role in T cell activation and proliferation. CD70 overexpression has been reported in various tumors such as renal cell carcinoma, glioblastoma, and non-small cell lung carcinoma and it’s being actively pursued as a therapeutic target.

Concentration:1 mg/mL

Immunogen:Recombinant human CD70 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000

Calculated MW:23 kDa

ObservedMW:27,54,81 kDa