Recombinant beta-2-Microglobulin Monoclonal Antibody

SKU: AN301849L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:beta-2-Microglobulin

Target Synonym:IMD;Beta-2-microglobulin form pI;CDABP;B2M;IMD43;B2MG;Beta 2 microglobin;Beta 2 microglobulin;Beta 2 microglobulin precursor;Beta chain of mhc class 1 proteins;Beta chain of MHC class I molecules;Beta-2-Microglobulin;Beta-2-microglobulin form pI 5.3;β2M;β2-Microglobulin;CDABP0092;HDCMA22P

Research Areas:Cardiovascular;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A561

UNIProt ID:P61769

Accession:

Background:β2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system. As an integral component of the MHC class I complex, β2-microglobulin plays a critically important role in immune system function. It has important relevance to cancer biology research; for example, research studies have shown that nearly one-third of diffuse large B cell lymphomas contain mutations that inactivate β2-microglobulin gene function, thereby allowing tumor cells to escape immune detection. In addition, β2-microglobulin has been identified as an amyloid preprotein with collagen-binding affinity; its accumulation in osteoarthritic lesions of long-term dialysis patients is reportedly a contributing factor to the condition known as amyloid osteoarthropathy.

Concentration:1 mg/mL

Immunogen:Recombinant human beta-2-Microglobulin fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:2000;IHC 1:500-1:1000

Calculated MW:14 kDa

ObservedMW:14 kDa