Recombinant ACE2 Monoclonal Antibody

SKU: AN301988L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:ACE2

Target Synonym:ACE;UNQ;PRO;Metalloprotease MPROT;Angiotensin-converting enzyme;ACE2;ACEH;ACEII;Angiotensin-converting enzyme 2;Angiotensin-converting enzyme homolog;Angiotensin-converting enzyme-related carboxypeptidase;ACE-related carboxypeptidase;Metalloprotease MPROT15;Processed angioten;UNQ868;PRO1885;ACEH;angiotensin-converting enzyme 2;ACE 2;ACE related carboxypeptidase;Angiotensin converting enzyme 2;Angiotensin converting enzyme homolog;Angiotensin converting enzyme like protein;Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2;Angiotensin I converting enzyme 2;DKFZP434A014;EC 3.4.17;metalloprotease MPROT 15;OTTHUMP00000022963;Processed angiotensin-converting enzyme 2

Research Areas:Cell Biology;Cardiovascular

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A708

UNIProt ID:Q9BYF1

Accession:

Background:ACE2 is a carboxypeptidase that catalyses the conversion of angiotensin I to angiotensin 1-9, or of angiotensin II to the vasodilator angiotensin 1-7. ACE2 is a critical component in the renin-angiotensin system (RAS). ACE2 is predominantly expressed in vascular endothelial cells of the heart and kidney and Leydig and Sertoli cells of the testis. The unique expression pattern of ACE2 determines its essential role in the regulation of cardiovascular and kidney functions, as well as fertility. ACE2 protein is localized mainly in the extracellular space with its carboxy-terminal end attached to the membrane via its transmembrane domain. Active ACE2 enzyme is secreted by cleavage at the amino terminus. Research studies have shown that ACE2 expression is elevated in human failing heart. ACE2 has also been identified as the receptor for SARS and SARS-CoV-2 coronaviruses.

Concentration:1 mg/mL

Immunogen:Peptide. This information is proprietary to PTMab.

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000;IHC 1:500-1:1000

Calculated MW:92 kDa

ObservedMW:100, 120 kDa