Recombinant 2B4/CD244 Monoclonal Antibody

SKU: AN300092P

Size::20μL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies

Abbreviation:CD244

Target Synonym:h2B;SLAM family member;Natural killer cell receptor 2B;NKR2B;SLAMF;CD244;2B4;NAIL;NKR2B4;Nmrk;SLAMF4;h2B4;Natural killer cell receptor 2B4;NK cell activation-inducing ligand;SLAM family member 4;2B4;C9.1;CD244 antigen;CD244 molecule;CD244 molecule natural killer cell receptor 2B4;CD244 natural killer cell receptor 2B4;F730046O15Rik;Ly90;member 4;Natural killer cell activation-inducing ligand;NK cell activation inducing ligand;NK cell activation inducing ligand NAIL;NK cell type I receptor protein 2B4;Non-MHC restricted killing associated;OTTHUMP00000027884;p38;signaling lymphocytic activation molecule 4;SLAM family

Research Areas:Immunology;Stem Cells

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB;IP

Isotype:IgG

Clonality:Rabbit Monoclonal

Clone NO.:6H3

UNIProt ID:Q9BZW8

Accession:

Background:CD244, known as 2B4, is a 38 kD type I transmembrane protein. It is a member of the CD2 subset of the immunoglobulin superfamily (IgSF) molecules. CD244 is expressed on NK cells, a subset of T cells (including most CD8+ T cells and γ/δ T cells), monocytes, basophils, and eosinophils. CD48 is the ligand of CD244. It has been reported that ligation of human CD244 results in enhanced NK cell cytotoxicity and cytokine production. Recent studies have shown that human CD244, like murine CD244, has both activating and inhibitory functions, which are dependent on the density of surface 2B4 expression, degree of ligation, and the level of the adaptor molecule SAP expression.

Concentration:1 mg/mL

Immunogen:Recombinant Human 2B4 / CD244 protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:2000;IP 1-4 μL/mg of lysate

Calculated MW:42 kDa

ObservedMW:28 kDa