RBL2 Monoclonal Antibody

SKU: BT-MCA3127

Size:100μL

Background:RBL2 is a Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Research_area:Cell Biology

Target_protein:RBL2

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:2C8A8

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:RBL2

Immunogen:Purified recombinant fragment of human RBL2 (AA: 939-1139) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide.

Concentration:

Molecular weight(Da):128.4kDa

UniProt accession:Q08999

Synonyms:Rb2, P130

GeneID:5934