RBL1 Antibody, HRP conjugated - Cat. #: CSB-PA019398LB01HU

SKU: CSB-PA019398LB01HU

Size :50ug

Clone Number:

Aliases:107 kDa retinoblastoma-associated protein antibody; Cellular protein 107 antibody; Cellular protein p107 antibody; CP107 antibody; MGC40006 antibody; p107 antibody; PRB1 antibody; RBL1 antibody; RBL1_HUMAN antibody; Retinoblastoma like protein 1 antibody; retinoblastoma-like 1 (p107) antibody; Retinoblastoma-like protein 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P28749

Immunogen:Recombinant Human Retinoblastoma-like protein 1 protein (201-500AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 \'Lys-20\' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RBL1

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology; Stem cells