Rb(Phospho-Ser807/811) Rabbit Polyclonal Antibody

SKU: BT-AP12238

Size:100μL

Background:The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active| hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB)| bladder cancer| and osteogenic sarcoma.

Research_area:Cancer; Cell biology; Epigenetics and nuclear signaling

Target_protein:RB1

applications:WB

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Rb

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: P06400; Mouse: P13405; Rat: P33568

Synonyms:Rb ;Ser807/811 ; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

GeneID:Human: 5925; Mouse: 19645; Rat: 24708