Rb(Phospho Ser612) Polyclonal Antibody

SKU: BT-AP13594

Size:100μL

Background:The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Research_area:Cancer; Cell biology; Epigenetics and nuclear signaling

Target_protein:RB1

applications:IHC-p, IF, ELISA

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Retinoblastoma-associated protein

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):106159

UniProt accession:Human: P06400; Mouse: P13405

Synonyms:Retinoblastoma-associated protein; RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

GeneID:Human: 5925