Rat Yes Associated Protein 1,YAP1 ELISA KIT

SKU: E2470Ra

Size:96 Tests-1 Kit

Background:Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization. Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (By similarity). Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity). In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). {ECO:0000250|UniProtKB:P46937, ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16461361}.; [Isoform 4]: Attenuates p73-mediated cell death signaling in transcriptional repression-induced atypical death (TRIAD) of neurons. {ECO:0000269|PubMed:16461361}.; [Isoform 3]: Attenuates p73-mediated cell death signaling in transcriptional repression-induced atypical death (TRIAD) of neurons. {ECO:0000269|PubMed:16461361}.; [Isoform 2]: Attenuates p73-mediated cell death signaling in transcriptional repression-induced atypical death (TRIAD) of neurons. {ECO:0000269|PubMed:16461361}.

Research_area:

Applications:ELISA

Target_protein:Yap1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.016ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Yes Associated Protein 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q2EJA0

MASS(Da):50501

GeneID:363014

Synonyms:Yap1 Yap Yap65

Gene names:Yap1

Standard solution:16ng/ml