Rat X-Box Binding Protein 1, XBP1 ELISA Kit

SKU: E1507Ra

Size:96 Tests-1 Kit

Background:Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland. Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes. Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention. [Isoform 1]: Acts as a weak transcriptional factor. Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress. Binds to the ER stress response element (ERSE) upon ER stress. Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences. Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner. Binds to the CDH5/VE-cadherin gene promoter region.

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:XBP1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:1.43ng/L

Detection range:3-750ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:X-Box Binding Protein 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9R1S4

MASS(Da):29,665

GeneID:289754

Synonyms:Hepatocarcinogenesis-related transcription factor;HTF;X-box-binding protein 1;X-box-binding protein 1, cytoplasmic form;X-box-binding protein 1, luminal form;XBP 1;XBP1

Gene names:XBP1

Standard solution:800ng/L