Rat Synaptotagmin 1,SYT1 ELISA KIT

SKU: E2882Ra

Size:96 Tests-1 Kit

Background:Calcium sensor that participates in triggering neurotransmitter release at the synapse (PubMed:30107533). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes. {ECO:0000250|UniProtKB:P21579, ECO:0000269|PubMed:30107533}.; (Microbial infection) Receptor for C.botulinum neurotoxin type B (BoNT/B, botB); interaction is improved in the presence of gangliosides (PubMed:8144634, PubMed:14504267, PubMed:17167418). BoNT/B toxin binds to the membrane proximal vesicular domain of Syt1 (residues 32-51) (PubMed:14504267, PubMed:17167421). {ECO:0000269|PubMed:14504267, ECO:0000269|PubMed:17167418, ECO:0000269|PubMed:17167421, ECO:0000269|PubMed:8144634}.; (Microbial infection) Receptor for C.botulinum neurotoxin type G (BoNT/G, botG); unlike the case with BoNT/B, interaction is not improved in the presence of gangliosides (PubMed:15123599, PubMed:20219474). BoNT/G toxin binds to the vesicular domain of Syt1 (residues 32-53) (PubMed:15123599, PubMed:20219474). {ECO:0000269|PubMed:15123599, ECO:0000269|PubMed:20219474}.

Research_area:

Applications:ELISA

Target_protein:Syt1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:10.91ng/L

Detection range:20-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Synaptotagmin 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P21707

MASS(Da):47399

GeneID:25716

Synonyms:Syt1

Gene names:Syt1

Standard solution:8000ng/L