Rat serine 129 phosphorylated alpha synuclein,SNCA ELISA KIT

SKU: E2577Ra

Size:96 Tests-1 Kit

Background:Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity. {ECO:0000250|UniProtKB:P37840}.

Research_area:

Applications:ELISA

Target_protein:Snca

Reactivity:Rat

Assay type:Sandwich

Sensitivity:7.16ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:serine 129 phosphorylated alpha synuclein

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P37377

MASS(Da):14515

GeneID:29219

Synonyms:Snca

Gene names:Snca

Standard solution:3200ng/L