Rat Receptor Tyrosine-protein Kinase Erbb-2, ERBB2 ELISA Kit

SKU: E2460Ra

Size:96 Tests-1 Kit

Background:Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Interacts (preferentially with the tyrosine phosphorylated form) with CPNE3; this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner (By similarity). In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth (By similarity).

Research_area:Tags & Cell Markers; Signal Transduction; Cancer

Applications:ELISA

Target_protein:ERBB2

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.29ng/ml

Detection range:0.5-100ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Receptor tyrosine-protein kinase erbB-2

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P06494

MASS(Da):138,832

GeneID:24337

Synonyms:CD antigen CD340;Epidermal growth factor receptor-related protein;ERBB2;HER2/neu;neu;p185erbB2;p185neu;Proto-oncogene c-ErbB-2;Proto-oncogene Neu;Receptor tyrosine-protein kinase erbB-2

Gene names:Erbb2

Standard solution:128ng/ml