Rat Neuropilin-2 ELISA Kit PicoKine®

SKU: EK1345

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Rat

Applications: ELISA

Application Details:

Gene Name: NRP2

Specificity: Natural and recombinant rat Neuropilin-2

Background: NRP2 (Neuropilin-2), also called Npn2 or VEGF165R2, encodes a member of the neuropilin family of receptor proteins. The soluble NRP2 was secreted as a 62.5-kD protein following transfection in Chinese hamster ovary cells. The NRP2 gene is mapped to 2q33.3. The NRP2 gene contains 17 exons and spans about 112 kb. This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Mice with null mutations in genes encoding Sema3F, and its holoreceptor components Npn2 and plexin A3 (PLEXA3), exhibit increased dentate gyrus granule cell and cortical layer V pyramidal neuron spine number and size, and also aberrant spine distribution. Moreover, Sema3F promotes loss of spines and excitatory synapses in dissociated neurons in vitro, and in NRP2-null brain slices cortical layer V and dentate gyrus granule cells exhibit increased miniature excitatory postsynaptic current frequency. These disparate effects of secreted semaphorins are reflected in the restricted dendritic localization of NRP2 to apical dendrites and of Npn1 to all dendrites of cortical pyramidal neurons.

Immunogen: Expression system for standard: NS0; Immunogen sequence: Q23-D857

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Uniprot ID: O35276

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 81527

Protein Name: Neuropilin-2

Gene Full Name: neuropilin 2

Synonyms: neuropilin 2; 1110048P06Rik; N; Np; Np-2; Np2; Npn-2; Npn2; Neuropilin-2; NRP2