Rat Myeloid differentiation primary response protein MyD88,MYD88 ELISA KIT

SKU: E1674Ra

Size:96 Tests-1 Kit

Background:Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). {ECO:0000250|UniProtKB:P22366, ECO:0000250|UniProtKB:Q99836}.

Research_area:

Applications:ELISA

Target_protein:Myd88

Reactivity:Rat

Assay type:Sandwich

Sensitivity:17.11ng/L

Detection range:30-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Myeloid Differentiation Factor88

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q6Y1S1

MASS(Da):33856

GeneID:301059

Synonyms:Myd88

Gene names:Myd88

Standard solution:8000ng/L