Rat Legumain ELISA Kit PicoKine®

SKU: EK2100

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Rat

Applications: ELISA

Application Details:

Gene Name: Lgmn

Specificity: Natural and recombinant rat Legumain

Background: Legumain is a protein that in humans is encoded by the LGMN gene. It is mapped to 6q32. This gene encodes a cysteine protease, legumain, that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.

Immunogen: Expression system for standard: NS0; Immunogen sequence: V18-N325

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Reconstitution:

Reference:

Uniprot ID: Q9R0J8

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 63865

Protein Name: Legumain

Gene Full Name: legumain

Synonyms: AEP; cysteine 1; Legumain; LGMN; LGMN1; PRSC1