Rat Interleukin-6 receptor subunit beta,IL-6RB ELISA KIT

SKU: E1560Ra

Size:96 Tests-1 Kit

Background:Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activate the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (By similarity). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop. Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). {ECO:0000250|UniProtKB:P40189, ECO:0000250|UniProtKB:Q00560}.

Research_area:

Applications:ELISA

Target_protein:Il6st

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.93ng/L

Detection range:2-600ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin 6 beta

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P40190

MASS(Da):102450

GeneID:

Synonyms:Il6st

Gene names:Il6st

Standard solution:640ng/L