Rat Glypican-3, GPC-3 ELISA Kit

SKU: E0884Ra

Size:96 Tests-1 Kit

Background:Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (By similarity). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:GPC3

Reactivity:Rat

Assay type:Sandwich

Sensitivity:5.29ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Glypican-3

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P13265

MASS(Da):67,049

GeneID:25236

Synonyms:Glypican-3;Glypican-3 alpha subunit;Glypican-3 beta subunit;GPC 3;GPC3;Intestinal protein OCI-5

Gene names:GPC3

Standard solution:2400ng/L