Rat Glutamate Decarboxylase 1, GAD1 ELISA Kit

SKU: E1353Ra

Size:96 Tests-1 Kit

Background:Glutamate decarboxylase 1 (brain, 67kDa) (GAD67), also known as GAD1, is a human gene. This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Research_area:Signal Transduction; Immunology

Applications:ELISA

Target_protein:GAD1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.09ng/ml

Detection range:0.2-60ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Glutamate decarboxylase 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P18088

MASS(Da):66,640

GeneID:24379

Synonyms:67 kDa glutamic acid decarboxylase;DCE1;gad;GAD1;Gad67;GAD-67;Glutamate decarboxylase 1;Glutamate decarboxylase 67 kDa isoform;SCP ;

Gene names:Gad1

Standard solution:64ng/ml