Rat Glucocorticoid Receptor, GR ELISA Kit

SKU: E0587Ra

Size:96 Tests-1 Kit

Background:Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed: 12917342). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). [Isoform A]: Has transcriptional activation and repression activity. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:NR3C1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:5.32ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Glucocorticoid Receptor

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P06536

MASS(Da):87,556

GeneID:24413

Synonyms:Glucocorticoid receptor;GR;NR3C1;Nuclear receptor subfamily 3 group C member 1

Gene names:NR3C1

Standard solution:2400ng/L