Rat E3 Ubiquitin-protein Ligase Trim63, TRIM63 ELISA Kit

SKU: E1951Ra

Size:96 Tests-1 Kit

Background:E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Research_area:Cell Biology

Applications:ELISA

Target_protein:TRIM63

Reactivity:Rat

Assay type:Sandwich

Sensitivity:7.56ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:E3 Ubiquitin-Protein Ligase Trim63

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q91Z63

MASS(Da):39,723

GeneID:140939

Synonyms:E3 ubiquitin-protein ligase TRIM63;MuRF1;MuRF-1;Muscle-specific RING finger protein 1;RING-type E3 ubiquitin transferase TRIM63;TRIM 63;TRIM63;Tripartite motif-containing protein 63

Gene names:TRIM63

Standard solution:3200ng/L