Rat Chromogranin-A, CGA ELISA Kit

SKU: E0557Ra

Size:96 Tests-1 Kit

Background:Strongly inhibits glucose induced insulin release from the pancreas. Catestatin inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Serpinin regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (By similarity). Serpinin and pGlu-serpinin can enhance both myocardial contractility (inotropy) and relaxation (lusitropy) and this cardio-stimulation requires a beta 1-adrenergic receptor/adenylate cyclase/cAMP/PKA pathway (PubMed:22459152).

Research_area:Signal Transduction; Neuroscience; Cancer; Metabolism

Applications:ELISA

Target_protein:CgA

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.93ng/ml

Detection range:2-600ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Chromogranin-A

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P10354

MASS(Da):52,024

GeneID:24258

Synonyms:Beta-granin;Catestatin;CgA;Chromogranin-A;GE-25;Pancreastatin;p-Glu serpinin precursor];Serpinin;Serpinin-RRG;WE-14

Gene names:Chga

Standard solution:640ng/ml