Rat Bone Morphogenetic Protein 4, BMP-4 ELISA Kit

SKU: E0266Ra

Size:96 Tests-1 Kit

Background:Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (By similarity). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (By similarity).

Research_area:Cardiovascular; Signal Transduction; Cancer; Developmental Biology

Applications:ELISA

Target_protein:BMP-4

Reactivity:Rat

Assay type:Sandwich

Sensitivity:1.01ng/L

Detection range:2-600ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Bone morphogenetic protein 4

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q06826

MASS(Da):46,541

GeneID:25296

Synonyms:BMP-2B;BMP-4;BOMPR4A;Bone morphogenetic protein 2B;Bone morphogenetic protein 4

Gene names:Bmp4

Standard solution:640ng/L