Rat ADP-ribosylation factor 1,ARF1 ELISA KIT

SKU: E3405Ra

Size:96 Tests-1 Kit

Background:GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD). {ECO:0000250|UniProtKB:P84077, ECO:0000269|PubMed:23889934}.

Research_area:

Applications:ELISA

Target_protein:Arf1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.13ng/ml

Detection range:0.25-16ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P84079

MASS(Da):20697

GeneID:64310

Synonyms:Arf1

Gene names:Arf1

Standard solution:32ng/ml