RAN Antibody - Cat. #: CSB-PA998992

SKU: CSB-PA998992

Size :50ul

Clone Number:

Aliases:Androgen receptor associated protein 24 antibody; Androgen receptor-associated protein 24 antibody; ARA 24 antibody; ARA24 antibody; Gsp1 antibody; GTP binding nuclear protein RAN antibody; GTP-binding nuclear protein Ran antibody; GTPase Ran antibody; Guanosine triphosphatase Ran antibody; LPS antibody; OK/SW-cl.81 antibody; ran antibody; RAN member RAS oncogene family antibody; RAN_HUMAN antibody; RanGTPase antibody; Ras like protein TC4 antibody; Ras related nuclear protein antibody; Ras-like protein TC4 antibody; Ras-related nuclear protein antibody; RASL2 8 antibody; TC 4 antibody; TC4 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P62826

Immunogen:Synthetic peptide of Human RAN

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:25-1:100

Background:RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RAN

Research Areas:Others