PYK2 Monoclonal Antibody

SKU: BT-MCA2892

Size:100μL

Background:PYK2: PTK2B protein tyrosine kinase 2 beta, also known as PTK2B, PKB, PTK, CAKB, FAK2, FRNK. Entrez Protein NP_004094. It is a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Research_area:Others

Target_protein:PYK2

applications:WB, IHC

Reactivity:Human

Clonality:Monoclonal

Clone ID:5E2D5

Host:Mouse

Isotype:Mouse IgG2a

Gene Symbol/ Name:PYK2

Immunogen:Purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):115.8kDa

UniProt accession:Q14289

Synonyms:PKB, PTK, CAKB, FAK2, FRNK, PTK2B

GeneID:2185