PUMA Polyclonal Antibody

SKU: BT-AP07510

Size:100μL

Background:BBC3 encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. BCL2 binding component 3 cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, BBC3 is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.

Research_area:Cell Biology

Target_protein:BBC3

applications:WB, ELISA

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:PUMA Antibody

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):20532/14459

UniProt accession:Human: Q9BXH1; Mouse: Q99ML1; Rat: Q80ZG6

Synonyms:BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis

GeneID:Human: 27113; Mouse: 170770; Rat: 317673