PTPN22 antibody , Cat. # FNab06936

SKU: FNab06936

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Acts as negative regulator of T-cell receptor(TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules(PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue(PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue(PubMed:16461343). Dephosphorylates the immune system activator SKAP2(PubMed:21719704). Positively regulates toll-like receptor(TLR)-induced type 1 interferon production(PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon(By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy(PubMed:23991106).

Immunogen:protein tyrosine phosphatase, non-receptor type 22(lymphoid)

Synonyms:PTPN8

Observed MW:79-95 kDa

Uniprot ID:Q9Y2R2

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IHC, IP

Recommended dilution:WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

Gene ID:26191

Research Area:Signal Transduction, Metabolism