PTPN11 Monoclonal Antibody

SKU: BT-MCA2963

Size:100μL

Background:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Research_area:Signal Transduction

Target_protein:PTPN11

applications:IHC, ICC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:6D9

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:PTPN11

Immunogen:Purified recombinant fragment of human PTPN11 (AA: 263-329) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):68.4kDa

UniProt accession:Q06124

Synonyms:CFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, MGC14433

GeneID:5781