PSME1 Polyclonal Antibody

SKU: E-AB-19193

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: PSME1

Target Synonym: 11S regulator complex alpha subunit;11S regulator complex subunit alpha;29 kD MCP activator subunit;29kD MCP activator subunit;Activator of multicatalytic protease subunit 1;IFI5111;IGUP I-5111;Interferon gamma IEF SSP 5111;Interferon gamma inducible protein 5111;Interferon gamma up regulated I 5111 protein;Interferon gamma up-regulated I-5111 protein;MGC8628;PA28a;PA28alpha;Proteasome (prosome; macropain) activator subunit 1 (PA28 alpha);Proteasome activator 28 subunit alpha;Proteasome activator complex subunit 1;Proteasome activator subunit 1;PSME1;PSME1;REG-alpha;REGalpha

Research Areas: Cancer;Cell Biology

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q06323

Accession:

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants.

Concentration: 0.78 mg/mL

Immunogen: Fusion protein of human PSME1

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:50-1:200

Calculated MW:

ObservedMW: