PSMD10 Antibody, Biotin conjugated - Cat. #: CSB-PA018899LD01HU

SKU: CSB-PA018899LD01HU

Size :50ug

Clone Number:

Aliases:26S proteasome non-ATPase regulatory subunit 10 antibody; 26S proteasome regulatory subunit p28 antibody; Ankyrin repeat protein antibody; dJ889N15.2 antibody; Gankyrin antibody; Hepatocellular carcinoma-associated protein p28 II antibody; p28 antibody; p28(GANK) antibody; Proteasome (prosome, macropain) 26S subunit, non ATPase, 10 antibody; Proteasome 26S S10 antibody; PSD10_HUMAN antibody; Psmd10 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O75832

Immunogen:Recombinant Human 26S proteasome non-ATPase regulatory subunit 10 protein (1-226AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PSMD10

Research Areas:Cancer; Cell biology