PSEN1 Antibody - Cat. #: CSB-PA695720

SKU: CSB-PA695720

Size :100ul

Clone Number:

Aliases:AD3 antibody; Ad3h antibody; FAD antibody; Homo Sapiens Clone CC44 Senilin 1 antibody; Presenilin-1 CTF12 antibody; Protein S182 antibody; PS 1 antibody; PS-1 antibody; PS1-CTF12 antibody; PSEN1 antibody; PSN1_HUMAN antibody; PSNL1 antibody; S182 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P49768

Immunogen:Synthesized peptide derived from Human presenilin 1.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Background:Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

Yanzhu Liu, J. Lipid Res., Dec 2004; 45: 2368 - 2376.
I. Imafuku, J. Cell Biol., Oct 1999; 147: 121.
Angeliki Louvi, Development, Jul 2004; 131: 3093 - 3105.
Wim G. Annaert, J. Cell Biol., Oct 1999; 147: 277.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PSEN1

Research Areas:Neuroscience?Cancer;Metabolism;Signal transduction