PRMT6 Antibody - Cat. #: CSB-PA856972LA01HU

SKU: CSB-PA856972LA01HU

Size :50ug

Clone Number:

Aliases:ANM6_HUMAN antibody; Chromobox protein homolog 7 antibody; FLJ10559 antibody; FLJ51477 antibody; Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 6 antibody; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 antibody; Histone-arginine N-methyltransferase PRMT6 antibody; HMT1 hnRNP methyltransferase like 6. antibody; HRMT1L6 antibody; OTTHUMP00000012633 antibody; PRMT 6 antibody; prmt6 antibody; Protein arginine methyltransferase 6 antibody; Protein arginine N methyltransferase 6 antibody; Protein arginine N-methyltransferase 6 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96LA8

Immunogen:Recombinant Human Protein arginine N-methyltransferase 6 protein (119-375AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200

Background:Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 \\\'Arg-2\\\' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 \\\'Lys-4\\\' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 \\\'Arg-3\\\' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PRMT6

Research Areas:Epigenetics and Nuclear Signaling