PRKRA Antibody, FITC conjugated - Cat. #: CSB-PA13669C0Rb

SKU: CSB-PA13669C0Rb

Size :50ug

Clone Number:

Aliases:DYT16 antibody; HSD14 antibody; Interferon inducible double stranded RNA dependent protein kinase activator A antibody; interferon-inducible double stranded RNA-dependent activator antibody; Interferon-inducible double stranded RNA-dependent protein kinase activator A antibody; PACT antibody; PKR associated protein X antibody; PKR associating protein X antibody; PKR-associated protein X antibody; PKR-associating protein X antibody; PRKRA antibody; PRKRA_HUMAN antibody; Protein activator of the interferon induced protein kinase antibody; Protein activator of the interferon-induced protein kinase antibody; Protein kinase antibody; Protein kinase interferon inducible double stranded RNA dependent activator antibody; RAX antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O75569

Immunogen:Recombinant Human Interferon-inducible double-stranded RNA-dependent protein kinase activator A protein (1-313AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at \'Lys-386\' at \'Ser-392\' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PRKRA

Research Areas:Epigenetics and Nuclear Signaling