PPM1D Polyclonal Antibody

SKU: E-AB-52172

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: PPM1D

Target Synonym: EC 3.1.3.16;p53 induced protein phosphatase 1;p53-induced protein phosphatase 1;PP2C delta;PP2C-delta;PP2CD;Ppm1d;PPM1D;Protein phosphatase 1D;protein phosphatase 1D magnesium-dependent delta isoform ;Protein phosphatase 2C delta isoform;Protein phosphatase 2C isoform delta;Protein phosphatase magnesium dependent 1 delta;Protein phosphatase magnesium-dependent 1 delta;Protein phosphatase Mg2+/Mn2+ dependent 1D;Protein phosphatase Wip1;Wild type p53 induced phosphatase 1;WIP 1;WIP1

Research Areas: Cancer;Signal transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: O15297

Accession:

Background: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

Concentration: 0.5 mg/mL

Immunogen: Fusion protein of human PPM1D

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:50-1:300

Calculated MW:

ObservedMW: