PPAR alpha(Phospho Ser21) Rabbit Polyclonal Antibody

SKU: BT-AP12079

Size:100μL

Background:Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand| the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids.|online information:Peroxisome proliferator-activated receptor entry|Belongs to the nuclear hormone receptor family. NR1 subfamily.|Contains 1 nuclear receptor DNA-binding domain.|subunit:Heterodimer with the retinoid X receptor. Interacts with NCOA3 and NCOA6 coactivators| leading to a strong increase of transcription of target genes. Also interacts with PPARBP coactivator in vitro. Interacts with AKAP13.|tissue specificity:Skeletal muscle| liver| heart and kidney.|

Research_area:Cancer; Cardiovascular; Epigenetics and nuclear signaling; Metabolism

Target_protein:PPARA

applications:WB, ELISA

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:PPAR alpha

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):51480

UniProt accession:Human: Q07869; Mouse: P23204; Rat: P37230

Synonyms:PPAR α ;Phospho Ser21; Peroxisome proliferator-activated receptor alpha; PPAR-alpha; Nuclear receptor subfamily 1 group C member 1

GeneID:Human: 5465; Mouse: 19013; Rat: 25747