POU5F1 Monoclonal Antibody

SKU: BT-MCA3745

Size:100μL

Background:This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.

Research_area:Epigenetics and Nuclear Signaling

Target_protein:POU5F1

applications:ICC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:2D9H4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:POU5F1

Immunogen:Purified recombinant fragment of human POU5F1 (AA: 136-360) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):38.5kDa

UniProt accession:Q01860

Synonyms:OCT3, OCT4, OTF3, OTF4, OTF-3, Oct-3, Oct-4

GeneID:5460