Porcine Signal Transducer and Activator of Transcription 1, STAT1 ELISA Kit

SKU: E0407Po

Size:96 Tests-1 Kit

Background:Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

Research_area:Others

Applications:ELISA

Target_protein:STAT1

Reactivity:Porcine

Assay type:Sandwich

Sensitivity:0.061ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Signal Transducer and Activator of Transcription 1

Species:Porcine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q764M5

MASS(Da):88,167

GeneID:396655

Synonyms:Signal transducer and activator of transcription 1;STAT 1;STAT1

Gene names:STAT1

Standard solution:48ng/ml