Porcine Clusterin, CLU ELISA Kit

SKU: E0545Po

Size:96 Tests-1 Kit

Background:Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity (By similarity). Following stress, promotes apoptosis (By similarity). Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (By similarity). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity).

Research_area:Immunology

Applications:ELISA

Target_protein:CLU

Reactivity:Porcine

Assay type:Sandwich

Sensitivity:0.59ng/mL

Detection range:1-400ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Clusterin

Species:Porcine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q29549

MASS(Da):51,775

GeneID:397025

Synonyms:CLI;CLU;Clusterin;Clusterin alpha chain;Clusterin beta chain;Complement cytolysis inhibitor;CP40

Gene names:CLU

Standard solution:480ng/mL